Who Should Take HIV PEP?
PEP is recommended after potential high-risk exposure to HIV, including:
- Unprotected sexual contact with a partner of unknown or positive HIV status
- Condom break or failure during intercourse
- Needle-stick injury or sharing needles
- Sexual assault
How to Take HIV PEP
- Take 1 dose once daily for 28 consecutive days
- Start treatment as soon as possible (ideally within 2 hours, and no later than 72 hours after exposure)
- Strict adherence is essential for effectiveness
If you miss a dose:
- Take it as soon as you remember
- If it is close to your next dose, skip the missed dose
- Do not take a double dose
Side Effects of HIV PEP
PEP is generally well tolerated, though some individuals may experience temporary side effects.
Common side effects:
- Nausea
- Fatigue
- Headache
- Diarrhea
These usually improve within a few days to weeks.
Less common but important side effects:
- Kidney function changes
- Sleep disturbances (associated with dolutegravir)
How to Manage Side Effects
- Take medication with food to reduce nausea
- Maintain adequate hydration
- Take medication at a consistent time daily
- Seek medical advice if symptoms persist or worsen
Conclusion
HIV PEP is a time-sensitive, highly effective intervention that can significantly reduce the risk of HIV infection after potential exposure. Early initiation and full adherence to the 28-day regimen are critical for success.
Seek medical attention immediately if exposure is suspected.

